2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W009081R
    Tricosanoic acid (Standard) 2433-96-7 98%
    Naringenin (Standard) is the analytical standard of Naringenin. This product is intended for research and analytical applications. Naringenin is the predominant flavanone in Citrus reticulata Blanco; displays strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity.
    Tricosanoic acid (Standard)
  • HY-W009162S
    Cytidine 5′-monophosphate-15N3 disodium 98%
    Cytidine 5′-monophosphate-15N3 (disodium) is the 15N labeled Cytidine 5'-monophosphate disodium. Cytidine 5'-monophosphate (5'-Cytidylic acid) disodium is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate disodium consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
    Cytidine 5′-monophosphate-15N3 disodium
  • HY-W009371A
    D-Ribose 5-phosphate 4300-28-1 98%
    D-Ribose 5-phosphate is an intermediate of the oxidative branch of the pentose phosphate pathway (PPP) and an end product of the nonoxidative branch of the PPP. D-Ribose 5-phosphate is used in the synthesis of nucleotides and nucleic acids.
    D-Ribose 5-phosphate
  • HY-W009417R
    Cedryl acetate (Standard) 77-54-3 98%
    Cedryl acetate (Standard) is the analytical standard of Cedryl acetate. This product is intended for research and analytical applications. Cedryl acetate is an orally active α-glucosidase inhibitor with an IC50 of 94 μM against yeast α-glucosidase. Cedryl acetate reduces high-fat diet-induced body weight gain, visceral fat pad weight, adipocyte hypertrophy, hepatic lipid accumulation, glucose intolerance, insulin resistance and gluconeogenesis. Cedryl acetate can be used in the research of obesity and obesity-related metabolic syndrome.
    Cedryl acetate (Standard)
  • HY-W009516R
    Dibenzyl disulfide (Standard) 150-60-7 98%
    Dibenzyl disulfide (Standard) is the analytical standard of Dibenzyl disulfide. This product is intended for research and analytical applications. Dibenzyl disulfide is an endogenous metabolite.
    Dibenzyl disulfide (Standard)
  • HY-W009731R
    Dibenzoylmethane (Standard) 120-46-7
    Dibenzoylmethane (Standard) is the analytical standard of Dibenzoylmethane. This product is intended for research and analytical applications. Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2.
    Dibenzoylmethane (Standard)
  • HY-W010031S
    1-Methyluric acid-13C4,15N3 1173022-91-7 98%
    1-Methyluric acid-13C4,15N3 is the 13C and 15N labeled 1-Methyluric acid. 1-Methyluric acid acts on the urinary bladder mucosa and increases the blood glucose, insulin, triglyceride, and cholesterol levels.
    1-Methyluric acid-13C4,15N3
  • HY-W010270A
    Aurothiomalate disodium 74916-57-7 98%
    Aurothiomalate (disodium) is a TRPA1 inhibitor. Aurothiomalate (disodium) inhibits NF-κB activation and iNOS expression. Aurothiomalate (disodium) promotes M2 transformation of macrophages and increases the expression of TREM-2 and arginase-1. Aurothiomalate (disodium) can be used in the study of liver fibrosis/cirrhosis and arthritis.
    Aurothiomalate disodium
  • HY-W010381S
    2-Methylsuccinic acid-d6 347840-08-8 99.9%
    2-Methylsuccinic acid-d6 is the deuterium labeled 2-Methylsuccinic acid. 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy.
    2-Methylsuccinic acid-d6
  • HY-W010450S
    Thymine-d4 200496-79-3 98%
    Thymine-d4 is the deuterium labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.
    Thymine-d4
  • HY-W010452S
    3-Hydroxybutyric acid-d2 sodium 352439-00-0 98%
    3-Hydroxybutyric acid-d2 (sodium) is the deuterium labeled 3-Hydroxybutyric acid sodium. 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids.
    3-Hydroxybutyric acid-d2 sodium
  • HY-W010476R
    2,3,5-Trimethylpyrazine (Standard) 14667-55-1 98%
    2,3,5-Trimethylpyrazine (Standard) is the analytical standard of 2,3,5-Trimethylpyrazine. This product is intended for research and analytical applications. 2,3,5-Trimethylpyrazine is an endogenous metabolite.
    2,3,5-Trimethylpyrazine (Standard)
  • HY-W010476S
    2,3,5-Trimethylpyrazine-d9 85735-49-5 98%
    2,3,5-Trimethylpyrazine-d9 is the deuterium labeled 2,3,5-Trimethylpyrazine. 2,3,5-Trimethylpyrazine is an endogenous metabolite.
    2,3,5-Trimethylpyrazine-d9
  • HY-W010516R
    2-Methylvaleric acid (Standard) 97-61-0 98%
    2-Methylvaleric acid (Standard) is the analytical standard of 2-Methylvaleric acid. This product is intended for research and analytical applications. 2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].
    2-Methylvaleric acid (Standard)
  • HY-W010589R
    L-2-Aminobutyric acid (Standard) 1492-24-6
    L-2-Aminobutyric acid (Standard) is the analytical standard of L-2-Aminobutyric acid. This product is intended for research and analytical applications. L-2-Aminobutyric acid is a non-proteinogenic amino acid that exists in human tissues and body fluids. L-2-Aminobutyric acid is formed by the transamination of oxobutyric acid. L-2-Aminobutyric acid can serve as a precursor for anticonvulsant and anti-tuberculosis agents and is a key intermediate in the chemical and pharmaceutical industries.
    L-2-Aminobutyric acid (Standard)
  • HY-W010649R
    Isoxazole (Standard) 288-14-2
    Amfenac (Sodium Hydrate) (Standard) is the analytical standard of Amfenac (Sodium Hydrate). This product is intended for research and analytical applications. Amfenac Sodium Hydrate is a COX-2 inhibitor.
    Isoxazole (Standard)
  • HY-W010697S
    Cholesteryl linoleate-d11 98%
    Cholesteryl linoleate-d11 is deuterium labeled Cholesteryl linoleate. Cholesteryl linoleate is shown to be the major cholesteryl ester contained in LDL and atherosclerotic lesions.
    Cholesteryl linoleate-d11
  • HY-W010736S
    1,2-Dipalmitoyl-sn-glycerol-d9 1872379-48-0 98%
    1,2-Dipalmitoyl-sn-glycerol-d9 is a deuterated labeled 1,2-Dipalmitoyl-sn-glycerol. 1,2-Dipalmitoyl-sn-glycerol is an endogenous metabolite.
    1,2-Dipalmitoyl-sn-glycerol-d9
  • HY-W010973S
    5-Hydroxytryptamine-d4 creatinine sulfate monohydrate 2687960-56-9 98%
    5-Hydroxytryptamine-d4 creatinine sulfate monohydrate is the deuterium labeled 5-Hydroxytryptamine creatinine sulfate monohydrate. 5-Hydroxytryptamine creatinine sulfate monohydrate is an endogenous metabolite.
    5-Hydroxytryptamine-d4 creatinine sulfate monohydrate
  • HY-W011012R
    Adenosine 5'-monophosphate disodium (Standard) 4578-31-8 98%
    Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes.
    Adenosine 5'-monophosphate disodium (Standard)
Cat. No. Product Name / Synonyms Application Reactivity